Which C-peptide assay do you use? Increasing need for describing C-peptide assay performance

Pim Dekker; Martine de Vries; Henk-Jan Aanstoot; Joost Groen

doi:10.5114/pedm.2022.113741

eISSN: 2083-8441
ISSN: 2081-237X

Pediatric Endocrinology Diabetes and Metabolism

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abstract:

Letter to the Editor

Which C-peptide assay do you use? Increasing need for describing C-peptide assay performance

Pim Dekker

¹

,

Martine de Vries

¹

,

Henk-Jan Aanstoot

¹

,

Joost Groen

²

Center for Pediatric and Adult Diabetes Care and Research, Rotterdam, The Netherlands
Department of Clinical Chemistry, IJsselland Ziekenhuis, Capelle aan den IJssel, The Netherlands

Pediatr Endocrinol Diabetes Metab 2022; 28 (1): 101–103

DOI: https://doi.org/10.5114/pedm.2022.113741

Online publish date: 2022/03/03

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Many C-peptide assays are commercially available for research and routine use. However, not all assays yield consistent results, especially in the low concentration ranges. We searched the literature describing C-peptide measurements to assess which assays are mainly used in the diabetes research field and if they are specified. Percentages of publications on C-peptide measurements in type 1 diabetes (T1D), type 2 diabetes (T2D) and other forms of diabetes were 32%, 54% and 14%, respectively. In only 54% of the publications the used assay was specified. Information on detection limit, measurement range and variation was provided in 12%, 2% and 11% of publications, respectively. In 22% of all publications no C-peptides concentrations were mentioned. This may be a problem especially for T1D research, where measuring very low levels of C-peptide is becoming increasingly important and concordance between assays is low.

keywords:

Which C-peptide assay do you use? Increasing need for describing C-peptide assay performance

Pim Dekker 1 , Martine de Vries 1 , Henk-Jan Aanstoot 1 , Joost Groen 2

diabetes, C-peptide, assay, detection limit

Pim Dekker

¹

,

Martine de Vries

¹

,

Henk-Jan Aanstoot

¹

,

Joost Groen

²