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Folia Neuropathologica
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4/2023
vol. 61
 
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Original paper

Immunological markers of drug resistant epilepsy and its response to immunomodulatory therapy with ACTH in children

Magdalena Kaczorowska
1
,
Edyta Czekuć-Kryśkiewicz
2
,
Maciej Dądalski
3
,
Katarzyna Kotulska
1

1.
Department of Neurology and Epileptology, The Children’s Memorial Health Institute, Warsaw, Poland
2.
Department of Biochemistry, Radioimmunology and Experimental Medicine, The Children’s Memorial Health Institute, Warsaw, Poland
3.
Department of Gastroenterology, Hepatology, Feeding Disorders and Pediatrics, The Children’s Memorial Health Institute, Warsaw, Poland
Folia Neuropathol 2023; 61 (4): 360-370
Online publish date: 2023/10/05
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- Immunological.pdf  [0.13 MB]
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1. Aronica E, Bauer S, Bozzi Y, Caleo M, Dingledine R, Gorter JA, Henshall DC, Kaufer D, Koh S, Löscher W, Louboutin JP, Mishto M, Norwood BA, Palma E, Poulter MO, Terrone G, Vezzani A, Kaminski RM. Neuroinflammatory targets and treatments for epilepsy validated in experimental models. Epilepsia 2017; 58 Suppl 3 (Suppl 3): 27-38.
2. Baram TZ. What are the reasons for the strikingly different approaches to the use of ACTH in infants with West syndrome? Brain Dev 2001; 23: 647-648.
3. Bernardino L, Xapelli S, Silva AP, Jakobsen B, Poulsen FR, Oliveira CR, Vezzani A, Malva JO, Zimmer J. Modulator effects of interleukin-1beta and tumor necrosis factor-alpha on AMPAinduced excitotoxicity in mouse organotypic hippocampal slice cultures. J Neurosci 2005; 25: 6734-6744.
4. Culler GW, VanHaerents S. Immunologic treatments of seizures and status epilepticus. Semin Neurol 2020; 40: 708-718.
5. Dunn AJ, Gispen HW. How ACTH acts on the brain. Biobehav Rev 1977; 1: 15-23.
6. Fiest KM, Sauro KM, Wiebe S, Patten SB, Kwon CS, Dykeman J, Pringsheim T, Lorenzetti DL, Jetté N. Prevalence and incidence of epilepsy: A systematic review and meta-analysis of international studies. Neurology 2017; 88: 296-303.
7. Friedman A, Dingledine R. Molecular cascades that mediate the influence of inflammation on epilepsy. Epilepsia 2011; 52 Suppl 3: 33-39.
8. Guenther S, Bauer S, Hagge M, Knake S, Olmes DG, Tackenberg B, Rosenow F, Hamer HM. Chronic valproate or levetiracetam treatment does not influence cytokine levels in humans. Seizure 2014; 23: 666-669.
9. Gupta R, Appleton R. Corticosteroids in the management of the paediatric epilepsies. Arch Dis Child 2005; 90: 379-384.
10. https://stat.gov.pl/obszary-tematyczne/ludnosc/ludnosc/struktura-ludnosci,16,1.html (access 05.05.2022)
11. Ito M. Extremely low-dose ACTH therapy for West syndrome in Japan. Brain Dev 2001; 23: 635-641.
12. Kwan P, Arzimanoglou A, Berg AT, Brodie MJ, Allen Hauser W, Mathern G, Moshé SL, Perucca E, Wiebe S, French J. Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia 2010; 51: 1069-1077.
13. Labh R, Gupta R, Narang M, Halder S, Kar R. Effect of valproate and add-on levetiracetam on inflammatory biomarkers in children with epilepsy. Epilepsy Behav 2021; 125: 108358.
14. Liu ZS, Wang QW, Wang FL, Yang LZ. Serum cytokine levels are altered in patients with West syndrome. Brain Dev 2001; 23: 548-551.
15. Lux AL, Edwards SW, Hancock E, Johnson AL, Kennedy CR, Newton RW, O’Callaghan FJ, Verity CM, Osborne JP. United Kingdom Infantile Spasms Study. The United Kingdom Infantile Spasms Study (UKISS) comparing hormone treatment with vigabatrin on developmental and epilepsy outcomes to age 14 months: a multicentre randomised trial. Lancet Neurol 2005; 4: 712-717.
16. Lux AL, Edwards SW, Hancock E, Johnson AL, Kennedy CR, Newton RW, O’Callaghan FJ, Verity CM, Osborne JP. The United Kingdom Infantile Spasms Study comparing vigabatrin with prednisolone or tetracosactide at 14 days: a multicentre, randomised controlled trial. Lancet 2004; 364: 1773-1778.
17. Mayhan WG. Cellular mechanisms by which tumor necrosis factor-alpha produces disruption of the blood-brain barrier. Brain Res 2002; 927: 144-152.
18. O’Callaghan FJ, Edwards SW, Alber FD, Hancock E, Johnson AL, Kennedy CR, Likeman M, Lux AL, Mackay M, Mallick AA, Newton RW, Nolan M, Pressler R, Rating D, Schmitt B, Verity CM, Osborne JP; participating investigators. Safety and effectiveness of hormonal treatment versus hormonal treatment with vigabatrin for infantile spasms (ICISS): a randomised, multicentre, open-label trial. Lancet Neurol 2017; 16: 33-42.
19. Orsini A, Foiadelli T, Carli N, Costagliola G, Masini B, Bonuccelli A, Savasta S, Peroni D, Consolini R, Striano P. Rasmussen’s encephalitis: From immune pathogenesis towards targeted-therapy. Seizure 2020; 81: 76-83.
20. Pranzatelli MR. On the molecular mechanism of adrenocorticotrophic hormone in the CNS: neurotransmitters and receptors. Exp Neurol 1994; 125: 142-161.
21. Quirico-Santos T, Meira ID, Gomes AC, Pereira VC, Pinto M, Monteiro M, Souza JM, Alves-Leon SV. Resection of the epileptogenic lesion abolishes seizures and reduces inflammatory cytokines of patients with temporal lobe epilepsy. J Neuroimmunol 2013; 254: 125-130.
22. Riikonen R. A long-term follow-up study of 214 children with the syndrome of infantile spasms. Neuropediatrics 1982; 13: 14-23.
23. Siemes H, Siegert M, Aksu F, Emrich R, Hanefeld F, Scheffner D.CSF protein profile in infantile spasms. Influence of etiology and ACTH or dexamethasone treatment. Epilepsia 1984; 25: 368-376.
24. Sorel L, Dusaucy-Bauloye A. Findings in 21 cases of Gibbs’ hypsarrhythmia; spectacular effectiveness of ACTH. Acta Neurol Psychiatr Belg 1958; 58: 130-141.
25. Steinborn B, Zarowski M, Winczewska-Wiktor A, Wójcicka M, Młodzikowska-Albrecht J, Losy J. Concentration of Il-1b, Il-2, Il-6, TNF-a in the blood serum in children with generalized epilepsy treated by valproate. Pharmacol Rep 2014; 66: 972-975.
26. Sultana B, Panzini MA, Veilleux Carpentier A, Comtois J, Rioux B, Gore G, Bauer PR, Kwon CS, Jetté N, Josephson CB, Keezer MR. Incidence and prevalence of drug-resistant epilepsy: A systematic review and meta-analysis. Neurology 2021; 96: 805-817.
27. Türe E, Kamaşak T, Cora M, Şahin S, Arslan EA, Kaklıkaya N, Cansu A. Comparison of the serum cytokine levels before and after adrenocorticotropic hormone (ACTH) therapy in patients with infantile spasm. Seizure 2016; 41: 112-115.
28. Tütüncüoğlu S, Kütükçüler N, Kepe L, Coker C, Berdeli A, Tekgül H. Proinflammatory cytokines, prostaglandins and zinc in febrile convulsions. Pediatr Int 2001; 43: 235-239.
29. Verhelst H, Boon P, Buyse G, Ceulemans B, D’Hooghe M, Meirleir LD, Hasaerts D, Jansen A, Lagae L, Meurs A, Coster RV, Vonck K. Steroids in intractable childhood epilepsy: clinical experience and review of the literature. Seizure 2005; 14: 412-421.
30. Vezzani A, Granata T. Brain inflammation in epilepsy: experimental and clinical evidence. Epilepsia 2005; 46: 1724-1743.
31. Vigevano F, Cilio MR. Vigabatrin versus ACTH as first-line treatment for infantile spasms: a randomized, prospective study. Epilepsia 1997; 38: 1270-1274.
32. Virta M, Hurme M, Helminen M. Increased plasma levels of pro- and anti-inflammatory cytokines in patients with febrile seizures. Epilepsia 2002; 43: 920-923.
33. Xue-Ping W, Hai-Jiao W, Li-Na Z, Xu D, Ling L. Risk factors for drug-resistant epilepsy: A systematic review and meta-analysis. Medicine (Baltimore) 2019; 98: e16402.
34. Yildiz EP, Gunes D, Bektas G, Aksu Uzunhan T, Tatli B, Caliskan M, Aydinli N, Ozmen M. Predictive factors of drug-resistant epilepsy in children presenting under 2 years of age: experience of a tertiary center in Turkey. Acta Neurol Belg 2018; 118: 71-75.
35. Zuberi SM, Wirrell E, Yozawitz E, Wilmshurst JM, Specchio N, Riney K, Pressler R, Auvin S, Samia P, Hirsch E, Galicchio S, Triki C, Snead OC, Wiebe S, Cross JH, Tinuper P, Scheffer IE, Perucca E, Moshé SL, Nabbout R. ILAE classification and definition of epilepsy syndromes with onset in neonates and infants: Position statement by the ILAE Task Force on Nosology and Definitions. Epilepsia 2022; 63: 1349-1397.
Copyright: © 2023 Mossakowski Medical Research Centre Polish Academy of Sciences and the Polish Association of Neuropathologists. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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