An intriguing case of precocious puberty due to an ovarian mass in an infant

Devi Dayal; Keerthivasan Seetharaman; Prema Menon; Anshita Aggarwal; Gargi Das; Radhika Srinivasan

doi:10.5114/pedm.2019.85820

eISSN: 2083-8441
ISSN: 2081-237X

Pediatric Endocrinology Diabetes and Metabolism

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abstract:

Case report

An intriguing case of precocious puberty due to an ovarian mass in an infant

Devi Dayal

¹

,

Keerthivasan Seetharaman

¹

,

Prema Menon

²

,

Anshita Aggarwal

³

,

Gargi Das

¹

,

Radhika Srinivasan

⁴

Endocrinology and Diabetes Unit, Department of Paediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Department of Paediatric Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Department of Endocrinology, Department of Paediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Department of Cytology and Gynaecological Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

Pediatr Endocrinol Diabetes Metab 2019; 25 (2): 90-94

DOI: https://doi.org/10.5114/pedm.2019.85820

Online publish date: 2019/06/29

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We present a rare occurrence of precocious puberty (PP) probably due to an autonomous ovarian cyst in a 15-month-old girl who presented to us with growth spurt, breast and pubic hair development, and vaginal bleeding over the last few months. The clinical presentation was suggestive of central precocious puberty (CPP). However, the rapid progression of pubertal changes and occurrence of menarche at breast Tanner stage 2 indicated peripheral precocious puberty (PPP). Due to uncertainty of clinical diagnosis, investigations were conducted for CPP as well as PPP. The basal and peak stimulated LH concentrations were < 0.3 IU/l and < 2 IU/l, respectively, indicating PPP. However, the peak LH : FSH ratio was > 1, which is consistent with CPP. Abdominal imaging revealed an ovarian mass, which was laparoscopically excised, but the true nature of the mass could not be ascertained because the excised specimen showed only haemorrhage and features of ovarian torsion on histopathological examination. Regression of pubertal development occurred over a three-month period postoperatively.

keywords:

An intriguing case of precocious puberty due to an ovarian mass in an infant

Devi Dayal 1 , Keerthivasan Seetharaman 1 , Prema Menon 2 , Anshita Aggarwal 3 , Gargi Das 1 , Radhika Srinivasan 4

precocious puberty, pseudopuberty, central precocious puberty, autonomous ovarian cyst

Devi Dayal

¹

,

Keerthivasan Seetharaman

¹

,

Prema Menon

²

,

Anshita Aggarwal

³

,

Gargi Das

¹

,

Radhika Srinivasan

⁴