Insulin-like growth factor-1 (IGF-1) – structure and the role in the human body

Alicja Filus; Zygmunt Zdrojewicz

eISSN: 2083-8441
ISSN: 2081-237X

Pediatric Endocrinology Diabetes and Metabolism

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abstract:

Review paper

Insulin-like growth factor-1 (IGF-1) – structure and the role in the human body

Alicja Filus

,

Zygmunt Zdrojewicz

Pediatr Endocrinol Diabetes Metab 2014;22,4:161-169

Online publish date: 2015/08/31

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In the recent years, managed to broadly explore the structure and role of insulin-like growth factors type 1 and 2 (IGF1 I 2). They belong to the structure of polypeptide hormones homologous to proinsulin. They are characterized by a wide range of activities. IGF-1 is a key mediator of most tissue effects of growth hormone (GH). In addition to effects on growth processes of the body, is also an important factor for cell homeostasis, is subject to both endocrine and tissue-specific auto- and paracrine regulation. In this paper, the current, general knowledge on the structure, function and mechanism of biological effects of IGF-1 in the human body was presented. Attention was also drawn to the directions of use of IGf-1 in the treatment of other diseases than the diseases of the hypothalamic-pituitary and growth disorders in children.

keywords:

Insulin-like growth factor-1 (IGF-1) – structure and the role in the human body

Alicja Filus , Zygmunt Zdrojewicz

IGF-1, GH, IGFBP, receptor, diagnosis, therapy

Alicja Filus

,

Zygmunt Zdrojewicz